Vriligy 60 mg is typically taken orally with water, approximately 1 to 3 hours before anticipated sexual activity. It should be swallowed whole and not crushed or chewed. It can be taken with or without food. The effects of Vriligy 60 mg typically last for about 4 to 6 hours after ingestion. During this time, men may find it easier to delay ejaculation and prolong the duration of sexual activity.